Abstract. Objective: To provide population based data on the treatment requirements of infants with rhesus isoimmunisation. Setting: Twenty nine hospitals in. Letters to the Editor| Volume , ISSUE , P99, January 19, ALPHA- FETOPROTEIN AND RHESUS ISOIMMUNISATION. Save. PREVENTION OF RHESUS ISO-IMMUNISATION. C.A. Clarke, M.D., Sc.D. Cantab., F.R.C.P.. C.A. Clarke. Search for articles by this author. Show all authors .
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Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any ryesus in the text or for the misuse or misapplication of material in this work.
Except where otherwise stated, drug dosages and recommendations are for rnesus non-pregnant adult who isoo not breastfeeding. Rhesus hemolytic disease of the fetus and newborn, while by no means the frequent condition that it once was, remains a problem that requires constant vigilance and attention.
Although effective prophylaxis is available it must be properly used. Postpartum prophylaxis with anti-D immunoglobulin should be given within oso hours of birth to all RhD-negative women who give birth to a RhD-positive baby, or a baby whose RhD status cannot be determined, irrespective of their ABO status.
Anti-D immunoglobulin should be administered also to all RhDnegative women during pregnancy when immunjsation is an increased risk of fetomaternal bleeding. Routine use of anti-D immunoglobulin at 28 or 34 weeks of pregnancy for all Rh-negative women is of value as well, but the costs of such a programme are high and together with the limited supplies of anti-D immunoglobulin may preclude this in some countries.
[Mechanism of rhesus iso-immunisation and of its prevention].
Rhesus iso-immunization has become sufficiently rare, and the treatment sufficiently complex, to warrant regionalization of care for these women and babies. Hopefully, this may facilitate adequate evaluation of the methods used for imnunisation and treatment, none of which have been as yet subjected to controlled trials. Access to the complete content on Oxford Medicine Online requires a subscription or purchase.
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