This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez. Definition: The epithelial cell rests of Malasse are discrete clusters of residual cells from Hertwig’s epithelial root sheath (HERS) that didn’t. The authors performed a PubMed search on the term “epithelial rests” alone or in combination with “Malassez.” Relevant articles were categorized into primary.

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However, later Trowbridge and Shibata 19 identified mitotic activity in epithelium rests in experimental studies with animal models.

[Epithelial cell rests of Malassez: tissue, cell, and molecular biology].

To understand the rational basis of regenerative procedures, a better understanding of the events associated with the formation of periodontal components will help to establish reliable strategies for clinical practice. Report based on literature review.

Orthodontic treatment, in turn, is essentially a periodontal event that involves an epihhelial inflammatory response during its initial phase. ERM incidence decreased with increasing age. The fibers and glands of the periodontal membrane. References Publications referenced by this paper. Vascular changes in the periodontal ligament after epitheliall of orthodontic forces. Among young patients, most ERM were located in the malsssez area and accumulated at the apex with increasing age.

Received Mar 7; Accepted Apr ERM distributed around the tooth root, forming something like a fishing net. The ultrastructural characteristics of these cells provided evidence that they could be involved in mediating resfs in the root resorption process, opening malasdez for further research in this direction.

The ERM is a major tissue structure, with functions in maintaining the homeostasis of periodontal tissue, including the maintenance of orthodontic movement. The capacity to repair periodontium and to prevent cementum damages were connected with this process. Furthermore, prostaglandins are important mediators of inflammation that play a key role in orthodontic movement, being synthesized by cyclooxygenases COX.


Alveolodental ankylosis is characterized by the absence of tooth elastin due to the loss of periodontal ligament cells associated with root resorption. The ERM cells indicated to present many functions at tooth movement after orthodontic forces.

This role is contrary to the events resulting from the induced orthodontic tooth movement. These molecules have proven potential for bone remodelling throughout life.

As for the most frequent types of REM, small and differentiated ones decrease with age, while proliferative ones increase with age. Find articles by David Normando. To date, no periodontal-regenerative procedures provide predictable clinical outcomes. These molecules have proven potential for bone remodelling throughout life.

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epithelial cell rests of Malassez – – Human pathology

Oral histology and embryology. Three morphological variations were observed: Cementoblasts are involved in the process of remodelling and repair of the root surface. J Period Res ; 41 4 Skills gained at the workshop are now malqssez to bring advanced, pain reduced dental treatment to South African consumers. Thank you Scivision for a great opportunity. Collagen renewal Collagen plays a key role in supporting the tensile forces; periodontal ligament compression and its renewal are extremely important epituelial maintaining the ligament space and protecting the tissue from mechanical forces.

J Mol Hist ; Evidence for a role of odontogenic epithelium in maintaining the periodontal space.

Epithelial cell rests of Malassez – Wikipedia

Direct stimulation of bone resorption by epidermal growth factor. Stem Cell and Dev ; 21 An ultrastructural evaluation of the relationship between epithelial rests of Malassez and orthodontic root resorption and repair in man. This result suggests the participation of ERM in the regeneration and repair of cementum.

Topics Discussed in This Paper. Through scanning electron microscopy and immunohistochemistry, Ten Cate 18 reported lower metabolic activity in cells of remaining epithelial components, suggesting a possible role of ERM should be disregarded in adult patients. Loe and Waerhaug 17 were the first to suggest a compatible function for ERM, having described the spatial distribution of these structures around the tooth root.


ERM are found within the periodontal ligament. Therefore, the persistence of ERM in the periodontal ligament is essential to the maintenance of periodontal homeostasis. The ERM represent the only odontogenic epithelial structure able to persist in the periodontal ligament in adulthood, as that is the only structure able to maladsez in situations in which the periodontal ligament tissue is affected.

These structures thus came to be known as the “epithelial rests of Malassez”, receiving the eponymous name of its principal investigator. Hyalinization during orthodontic tooth movement kalassez systematic review on tissue reactions.

Pathology by regions G. The latter also promote release of bone matrix proteins, BMP-2, osteopontin, osteoprotegerin and sialoprotein, proteins that aid in the repair and periodontal regeneration phase, aside from contributing to the repair of cementum itself.

Although there is no general agreement on the functions of the epithelial cell rests of Malassez, accumulating evidence suggests that the putative roles of the epithelial cell rests of Malassez in adult periodontal ligament include maintaining periodontal ligament homeostasis to prevent ankylosis and maintain periodontal ligament space, to prevent root resorption, to serve as a target during periodontal ligament innervation and to contribute to cementum repair.

Epub July 2.

After the application of force, the change in the levels of periodontal capillary pressure can trigger blood supply dysfunction until its collapse, according to the force applied. Otherwise, more studies are necessary to clarify these functions and consequences in daily epithellal practice. Cited by Google Similars in Google.

epithelial cell rests of Malassez

Retrieved from ” https: Proliferation epithelual epithelial rests of Malassez during experimental tooth movement. Am J Orthod Dentofacial Orthop. These cell rests proliferate to form epithelial lining of various odontogenic cysts such as radicular cyst under the influence of various stimuli.