The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by. Abstract: Apium graveolens (celery) is an edible and traditionally medicinal plant worldwide, among others for the treatment of hypertension. Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic mean arterial blood pressure and heart rate in normotensive and hypertensive rats.

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Application of apium graveolens in treatment of hypertension.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Angiotensin II-mediated vascular smooth muscle cell growth signaling. Flavor enhancement of chicken broth from boiled ggraveolens constituents. Rat isolated cardiomyocytes insulin-induced hypertrophy.

Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: A clinical study reported that mg of saffron tablets administered for 7 days were able to significantly reduce the SBP and mean arterial pressure in healthy humans by 11 and 5 gaveolens, respectively Modaghegh et al.

Danshen’s endothelium-dependent relaxations occur via an NO-dependent mechanism Chan et al. Endothelial dysfunction anticipates the progression of anatomically overt vascular disease, which robustly correlates with hypertension.

Effects of aqueous celery Apiumgraveolens extract on lipid parameters of rats fed a high fat diet. Ginseng is prepared and administered in various forms, either as a solid: Applications From the previous hyeprtension, A.

Likewise, administration of an intravenous bolus of Citronellol, an acyclic monoterpenoid isolated from lemongrass, to male Wistar rats produced a hypotensive response. Green tea diet decreases Hypertensuon induced oxidative stress in mice by up-regulating antioxidant enzymes.

Apiumgraveolens modulates sodium valproate-induced reproductive toxicity in rats.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Heterogeneous triterpenoid saponins and steroid glycosides or ginsenosides or panaxosides are the active principle components of ginseng Valli and Giardina, ; Kim, Alternative and complementary medicine for preventing and treating cardiovascular disease. Safety evaluation of saffron Crocus sativus tablets in hypertensino volunteers. Antioxidant and drug detoxification potentials of Hibiscus sabdariffa anthocyanin extract. All authors contributed to the writing.


The data suggested that celery extracts possess hypotensive properties in rats and should be further investigated as a potential intervention for HTN in humans. Hawthorns hawberry or thorn apple plants are shrubs that belong to a genus comprising almost species Tassell et al.

Statistical analysis showed a significant difference between all treatment groups hexanic, methanolic, and aqueous-ethanolic extract and negative control groups. Benefits, adverse effects and drug interactions of herbal therapies with cardiovascular effects.

Results All extracts caused concentration-dependent relaxation in precontracted aortic rings with and graveolns endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A.

Commonly used antihypertensive plants with anti-inflammatory activity. Morelos State University; Despite having these multifarious therapeutic effects, garlic also produces a few minor side effects.

This is thought to occur through the reaction between NO and the sulfide components of garlic Ku et al. J Agric Food Chem. According to the previous researches, no toxicity has been reported in the administration of different doses of celery seeds.

Regulation of gene expression by cyclic GMP. Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum. Apium graveolens celery The hypotensive effect of celery zpium been reported in in vivo animal studies.

In conclusion, celery leaf extract with its blood pressure and lipid lowering effects, can be considered as hy;ertension antihypertensive agent in chronic treatment of elevated SBP. Lipid profiles were determined by auto analysis. A randomized, double-blind placebo-controlled clinical trial of the effects of N.

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Role of TNF-alpha in vascular dysfunction. Suppressive effects of extracts from the aerial part of Coriandrum sativum L. Shah S, Mohan M. The relaxant effect geaveolens ginseng saponin on the bladder and prostatic urethra: Journal of ethnopharmacology, 83 3: An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma.


In addition to exhibiting antihypertensive effects, B. Cardio protective effect of Coriandrum sativum L. Endothelial cells The endothelial cell layer is no longer considered as an inert entity.

Reactive oxygen species and yypertension function—role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases. Vascular endothelial function and hypertension: Chronic NF-kappaB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats.

Abstract Objective To investigate vasorelaxant effect of organic extracts from Apium graveolens A. Use of OTC and herbal products in patients with cardiovascular disease. A key molecule that regulates oxidative stress in VSMCs is the transcription factor erythroid 2-related factor 2 Nrf2, or nuclear factor erythroid 2-like 2.

Tehran University Medical Journal

Growth factors impel the cell into entering cell cycle until the G1 phase, the first check point Marx et apiuj. It appears to be independent of ATP-sensitive potassium channels, but possibly involves a calcium channel antagonism and cyclooxygenase metabolite Nguelefack et al. Hypotensive effect of aqueous saffron extract Crocus sativus L.

In the same context, this relaxation may be aided by ginseng’s ability to diminish secretion of adrenal catecholamines in hypertensive rats Jang et al.